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Date of Issue : Apr 2002 1. IDENTIFICATION
General Product Name : THIOUREA Other Names : THIOCARBAMIDE ; ISOTHIOUREA THIOCARBONIC ACID DIAMIDE ; 2-THIOUREA UN No. : N/A Dangerous Goods Class : None Allocated Subsidiary Risk : None Allocated Hazchem Code : N/A Pack Group : 0 EPG : N/A Poisons Schedule : 6 Uses : Mainly used in medicine, textile, dyeing, paper-making, photograph, synthetics, resin, electroplating, making blue-print, boiler-cleaning, metallurgy, etc.
1.1 Physical Description / Properties
Appearance : White lustrous crystals with a bitter taste. Formula : CH4N2S Boiling Point : DEC deg C Melting Point : 170 deg C Vapour Pressure : N/A Specific Gravity : 1.41 (water = 1) Flash Point : N/A pH : N/A () Solubility in water : 135 g/l (25 deg C) Flammability Limits (as percentage volume in air) Lower Explosion Limit : N/A Upper Explosion Limit : N/A 1.2 Other Properties
Soluble in cold water, ammonium thiocyanate solution and alcohol, nearly insoluble in ether. Vapour density = 2.6 1.3 Ingredients
2. HEALTH HAZARD INFORMATION
2.1 Health Effects - Acute Swallowed
Harmful if swallowed. May cause allergic reaction characterised by a rash. May cause severe irritation of the digestive tract. Eye
May cause eye irritation. Skin
May cause skin irritation. May be absorbed through the skin in harmful amounts. May cause skin sensitisation, an allergic reaction, which becomes evident upon re-exposure to this material. Inhaled
May cause respiratory tract irritation. 2.2 Health Effects - Chronic
Chronic ingestion may cause liver damage. May cause cancer according to animal studies. May cause reproductive and foetal effects. Prolonged or repeated exposure may cause thyroid damage.
2.3 First Aid
Swallowed
If victim is conscious and alert, give 2 - 4 cupfuls of milk or water to drink. Never give anything by mouth to an unconscious person. Get medical attention immediately. Induce vomiting by giving one teaspoon of Ipecac syrup. Call a immediately.
Eye
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
Skin
Immediately flush skin with plenty of water for at least 15 minutes. Remove contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Inhaled
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention immediately.
First Aid Facilities
Ensure an eye bath and safety shower are available and ready for use.
2.5 Advice to Doctor
Treat symptomatically based on judgement of doctor and individual reactions of patient. Material may cause depression of bone marrow.
2.6 Toxicity Data
Oral LD50 = 125 mg/kg (Rat) Dermal LD50 = >2800 mg/kg (Rabbit) Inhalation LC50 = >170 mg/m3/4hr (Rat) Carcinogenicity : Category 2 Carcinogen - probable human carcinogen. Thiourea has been observed to cause tumours in the liver, lungs, ears, skin and thyroid of rats. Morphological transformations have been observed in rat and hamster embryos exposed to thiourea. Developmental abnormalities of the musculoskeletal and central nervous system were observed in rats administered thiourea orally 12 days after conception. The rate of post-implantation increased in rats administered thiourea orally 12 days after conception. RTECS reports DNA inhibition studies in human fibroblasts, lymphocytes and Hela cells. Unscheduled DNA synthesis and DNA damage studies have also been reported
3. PRECAUTIONS FOR USE
3.1 Exposure Standards
No exposure limit has been established for htis product by Worksafe however the following exists for nuisance dusts : TWA 10 mg/m3.
3.2 Engineering Controls
Ensure adequate ventilation to maintain airborne concentrations to a minimum, including the use of local and/or general exhaust ventilation.
3.3 Personal Protection
Eyes - wear appropriate protective eyeglasses or chemical safety goggles. Skin - wear appropriate protective gloves and clothing to minimise/prevent skin contact. Respiratory - wear an appropriate respirator when dusty conditions prevail. Wash hands and face thoroughly after handling and before work breaks, eating, drinking, smoking and using toilet facilities.
3.4 Flammability
Non combustible material. SAFE HANDLING INFORMATION
4.1 Storage / Transport
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Workers should wear protective clothing to keep all skin covered during handling.
4.2 Packaging / Labelling UN No. N/A Class None Allocated Sub Risk None Allocated Hazchem Code N/A Pack Group 0 EPG No. N/A Shipping Name THIOUREA Hazard HARMFUL DANGEROUS FOR THE ENVIRONMENT
Risk Phrases R22 Harmful if swallowed. R40 Possible risk of irreversible effects. R51/53 Toxic to aquatic organisms; may cause long term adverse effects in the aquatic environment.
Safety Phrases S2 Keep out of the reach of children. S22 Do not breathe dust. S24 Avoid contact with skin. S36/37 Wear suitable protective clothing and gloves.
4.3 Spills and Disposal
Spills
Clean up personnel should wear full protective equipment including breathing apparatus if dusty conditions prevail. Avoid contact with skin and eyes.
Clean up spills immediately by gathering up and sweeping into suitable containers. Avoid raising dust. Hold for waste dispsoal. Ventilate area and wash spill site once material pickup has been completed.
Disposal
Dispose of in accordance with all Local, State and Federal regulations by incineration at an approved waste disposal facility. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
4.4 FIRE AND EXPLOSION HAZARD Fire / Explosion
Material will not burn or explode. Stable under normal conditions of use and temperatures. Material is incompatible with strong oxidising agent, dtrong acids, acrolein and hydrogen peroxide. Hazardous decomposition products include nitrogen oxides, carbon monoxide, sulphur oxides, carbon dioxide and nitrogen.
Extinguishing Media
Fire-fighter should wear full protective equipment including self-contained breathing apparatus. Material is not flammable. Use equipment/media appropriate to surrounding conditions, includiong carbon dioxide, dry chemical powder, and alcohol or polymer foam. 5 OTHER INFORMATION
Other Information
No data available
5.1 Contact Points
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The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use.
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